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deshmukh said that hpv vaccine should not be called a vaccine to prevent a sexually transmitted disease, but a vaccine to prevent cancer. Hpv is associated with a number of cancers in both women and men, including anal cancer. Anal cancer risk is associated with the practice of unprotected anal sex. Thats in large part because of the potential for hpv infection during anal sex. actress marcia cross (desperate housewives) and her doctors revealed wednesday that they believe her battle with anal cancer was caused by the same human papillomavirus (hpv.). Because cancer of the cervix, vagina and vulva is associated with hpv infection, people with a history of these cancers are at increased risk of anal cancer. In addition to infection with hpv, other risk factors for potentially developing anal dysplasia and anal cancer include poor immunity (such as resulting from organ transplants), being over age 50, cigarette smoking and injection drug use.