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Most anal cancers seem to be linked to infection with the human papillomavirus (hpv). While hpv infection seems to be important in the development of anal cancer, the vast majority of people with hpv infections do not get anal cancer. A great deal of research is now being done to learn how hpv might cause anal cancer. Anal cancer is a cancer which arises from the anus, the distal opening of the gastrointestinal tract. Symptoms may include bleeding from the anus or a lump near the anus. Other symptoms may include pain, itchiness, or discharge from the anus. Anal cancer is an uncommon malignancy that starts in the anus-- the opening at the end of the rectum. The american society of clinical oncology estimates that 8,300 cases of anal cancer will be. Has increased among both men (160) and women (78) from 1973 to 2000. 1, 2 although the incidence was consistently higher for women compared with men through 1995, the annual incidence from 1996 to 2000 was equal for men and women (2. 1 human papillomaviruses (hpv) have been implicated as a cause of cervical and other. anal squamous cell cancer is believed to be directly linked to the presence of a complex inflammatory process most commonly caused by hpv infection (particularly with serotypes 16 and 18) in the histologically unique area of the anal squamocolumnar epithelium. Aetiological parallel between anal cancer and cervical cancer. Malignancies that occur before and after anal cancer clues to their etiology. Anal squamous intraepithelial lesions are linked to hpv and are common in men who have sex with men (msm) and immunosuppressed patients, especially those living with hiv.