See detailed information below for a list of 55 causes of rectal mass, symptom checker, including diseases and drug side effect causes. Review causes of rectal mass causes symptom checker causes of rectal mass the following medical conditions are some of the possible causes of rectal mass. anal cancer is an uncommon malignancy that starts in the anus-- the opening at the end of the rectum. Anal herpes anal sex may spread the herpes viruses hsv-1 and hsv-2. Symptoms include painful sores around the anus that come and go.
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