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Anal sac tumors can cause elevation of the calcium level in the blood, which results in increased thirst, increased urination, decreased activity, decreased appetite, weight loss, vomiting, muscle weakness and low heart rate. Some anal sac tumors can produce a hormone that raises blood calcium, and this can cause some dogs to drink excessively, produce large amounts of dilute urine, or show other vague signs of illness such as poor appetite, weakness or vomiting. Anal sac adenocarcinoma is an uncommon condition affecting older dogs that can cause tumors to grow on the anal sacs. Fna of anal sac mass may differentiate perianal tumors from other tumor types but will rarely differentiate benign from malignant perianal tumors (benign anal sac tumors are very rare) caudal abdominal radiographs or, preferably, ultrasound, ct, or mri to assess sublumbar lymph node size. Anal glands are located on either side of the anus and normally produce secretions that are pushed when feces is evacuated from the rectum. An anal sac tumor is a tumor of made up of cells originating from the glands of the anal sac. These tumors can spread and therefore staging is recommended prior to surgery. To diagnose these tumors, a fine needle aspirate can be placed from the outside and. Anal sac adenocarcinomas make up 2 of skin tumors in dogs and less than 1 of skin tumors in cats. The tumors typically occur in older dogs and some studies suggest that females may be at higher risk of anal sac cancer. Apocrine gland anal sac adenocarcinomas first appear as small lumps associated with one of the anal sacs (rarely bilateral), but they can grow to a large size. Smaller tumors are undetectable without a rectal examination, while larger tumors can cause pain and straining to defecate. Between 25 and 40 percent of dogs with these tumors will also develop hypercalcaemia through secretion of parathyroid hormone-related proteinby the tumor. Although their incidence is low, neoplasms arising from the glandular epithelium of the anal sacs are almost invariably malignant adenocarcinomas. These tumors invade the surrounding soft tissues and frequently metastasize to regional lymph nodes. Anal sac adenocarcinomas have been reported in dogs but not in cats. Anal gland adenocarcinoma (aga) (also known as apocrine gland anal sac carcinoma adenocarcinoma or anal sac adenocarcinoma) is an uncommon cancer that arises from the apocrine glands in the walls of the anal sacs.