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After many trips to the doctors it was determined that the cancer has not spread at this time. You should ask for a c-kit test as anal melanoma is considered mucosal melanoma. Mucosal melanoma with the c-kit mutation may respond to gleevec. I know nothing about the margins required for anal melanoma and since your pet is negative elsewhere, the surgical margins are probably the first step. Oncologist (dr pecara) recommended petct scan and mri of brain. Gleevec has helped people with gist go into lengthy remission, and anywhere from 21-40 of people with mucosal melanoma show the same kit gene mutation. A new, ongoing, phase ii trial of gleevec therapy for metastatic melanoma patients was recently presented by dr. Carvajal at sloan kettering at asco 2009 as an interim update of results. This trial required all patients to have genetic sequencing of their tumors and limited enrollment to patients with specific mutations in kit (at exons 9, 11, 13, 17 or 18) andor amplification of kit. Talked oncologist team into starting gleevec anyway (march 2009). Have been essentially stable on the gleevec for over three years now. A patient with anal mucosal melanoma and metastases to lymph nodes harbored an amplified kit k642e mutation. Complete resolution of subcutaneous melanoma and nodules was achieved after a dose-escalation gleevec regimen.