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The organic nitrates are vasodilators, active on both arteries and veins. Nitro-bid for topical use contains lactose and 2 nitroglycerin in a base of lanolin, white petrolatum and purified water. 5 cm), as squeezed from the tube, contains approximately 15 mg of nitroglycerin. It can also be prescribed for people with circulation problems in the legs or other areas, and its one of several treatment options designed to address such issues. In addition, this drug is used in the treatment of anal fissures and hemorrhoids. Severe cases result in involuntary internal anal sphincter spasm and have traditionally been treated surgically with a lateral sphincterotomy. Investigators have demonstrated that nitric oxide causes relaxation of the smooth muscle of the anal canal, so topical nitroglycerin ointment preparations have recently been studied as an efficacious alternative to surgery.