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An anal fissure is a tear in the skin around the opening for bowel movements, also known as the anus or rectal area. Nitroglycerin belongs to the group of medicines called nitrates. It works to relax the muscles around the anus so there is less pressure in the area. You may be able to prevent an anal fissure by taking measures to prevent constipation. Eat high-fiber foods, drink fluids and exercise regularly to keep from having to strain during bowel movements. Find patient medical information for nitroglycerin rectal on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Nitroglycerin rectal is used to treat moderate to severe pain caused by chronic anal fissures (tears in the skin lining your rectum). If your infant has an anal fissure, be sure to change diapers frequently, wash the area gently and discuss the problem with your childs doctor. Rectal ointment 1 inch of ointment (375 mg of ointment equivalent to 1. 5 mg of nitroglycerin) intra-anally every 12 hours for up to 3 weeks comments-a finger covering such as plastic wrap, a disposable surgical glove, or a finger cot should be placed on the finger to apply ointment. 4 nitroglycerin ointment is an intra-anal formulation of nitroglycerin (glyceryl trinitrate) indicated for the treatment of chronic anal fissure pain. Black triangle nitroglycerin is a nitric oxide (no) donor, which reduces the increased anal canal pressure caused by a hypertonic internal anal sphincter, improving anodermal blood flow. When used to treat anal fissure pain, it is usually applied every 12 hours for up to 3 weeks. If you still have anal fissure pain after using the ointment for 3 weeks, call your doctor. An anal fissure is a tear in the lining of the anus, the opening where feces are excreted. The tear typically extends into a circular ring of muscle called the internal anal sphincter (). The fissure is described as acute if it has been present for less than six weeks or chronic if present for more than six weeks. Previous reports have suggested initial efficacy in the treatment of anal fissures. The aim of this study was to assess the longer-term usefulness of this treatment. Methods thirty-three patients with an anal fissure were treated with topical 0. 3 nitroglycerin ointment, applied to the anoderm three times per day and after bowel movements.