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An anal fissure is a tear in the skin around the opening for bowel movements, also known as the anus or rectal area. Nitroglycerin belongs to the group of medicines called nitrates. It works to relax the muscles around the anus so there is less pressure in the area. You may be able to prevent an anal fissure by taking measures to prevent constipation. Eat high-fiber foods, drink fluids and exercise regularly to keep from having to strain during bowel movements. Get emergency medical help if you have signs of an allergic reaction hives difficult breathing swelling of your face, lips, tongue, or throat. Rectal ointment 1 inch of ointment (375 mg of ointment equivalent to 1. 5 mg of nitroglycerin) intra-anally every 12 hours for up to 3 weeks comments-a finger covering such as plastic wrap, a disposable surgical glove, or a finger cot should be placed on the finger to apply ointment. 2 nitroglycerin ointment administered topically to the anus and anal canal twice daily for 6 weeks resulted in anal fissure healing in 15 of 25 (60) patients. Anal fissure is a painful condition that is caused by anodermal tearing after the passage of hard stool. Severe cases result in involuntary internal anal sphincter spasm and have traditionally been treated surgically with a lateral sphincterotomy. Indicated for treatment of moderate-to-severe pain associated with chronic anal fissures consider use if conservative treatment for acute symptoms of anal fissure fails cover finger with plastic-wrap, disposable surgical glove or a finger cot and measure 1-inch (375 mg of ointment equivalent to 1.).