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Documented to be the best non-surgical option for prevention and healing of anal fissures. Medications for treating anal fissures nitrate ointment your doctor may prescribe one of these to help raise blood flow to the anal canal and sphincter, which helps fissures get better faster. Botulinum toxin is a relatively new treatment for anal fissures. Botulinum toxin is a powerful poison thats safe to use in small doses. If you have an anal fissure, an injection of the toxin can be used to paralyse your sphincter muscle. These practices heal most fissures (80 to 90 percent) within several weeks to several months. However, when treatments fail and anal fissures persist or come back, other measures can be tried, including using hydrocortisone-containing suppositories, foams, or creams to reduce inflammation applying other creams and ointments. the main contraindication to surgery for an anal fissure is impaired fecal continence, a state that could be exacerbated by surgery. prescription drugs used to treat anal fissures that fail to heal with less conservative treatment are ointments containing anesthetics, steroids, nitroglycerin, and calcium channel blocking drugs. These type of fissures cannot be effectively cured with just non-surgical medical treatments (tabletscreams). Hence chronic anal fissure treatment will require surgical intervention. Documented to be the best non-surgical option for prevention and healing of anal fissures.